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Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.
- Source :
-
Cytokine . Feb2017, Vol. 90, p60-65. 6p. - Publication Year :
- 2017
-
Abstract
- We investigated whether IL-33 is involved in mucus overproduction and goblet cell hyperplasia in eosinophilic chronic rhinosinusitis (ECRS). IL-33 mRNA was significantly higher in the eosinophilic CRS group than in the non-eosinophilic CRS group from human nasal polyps. IL-33 induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 induced MUC5B and FOXA3 , and reduces FOXJ mRNA. In conclusion, our present study demonstrated that the direct evidence of IL-33 which lead to increase mucin gene and protein expression, as well as goblet cell hyperplasia. This study provides novel insights into the role of IL-33 on mucus overproduction in eosinophilic inflammation of human airways. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERLEUKIN-33
*MUCINS
*GENE expression
*HYPERPLASIA
*EPITHELIAL cells
*MUCUS
Subjects
Details
- Language :
- English
- ISSN :
- 10434666
- Volume :
- 90
- Database :
- Academic Search Index
- Journal :
- Cytokine
- Publication Type :
- Academic Journal
- Accession number :
- 121026212
- Full Text :
- https://doi.org/10.1016/j.cyto.2016.10.010