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Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.

Authors :
Ishinaga, Hajime
Kitano, Masako
Toda, Masaaki
D’Alessandro-Gabazza, Corina N.
Gabazza, Esteban C.
Shah, Said Ahmad
Takeuchi, Kazuhiko
Source :
Cytokine. Feb2017, Vol. 90, p60-65. 6p.
Publication Year :
2017

Abstract

We investigated whether IL-33 is involved in mucus overproduction and goblet cell hyperplasia in eosinophilic chronic rhinosinusitis (ECRS). IL-33 mRNA was significantly higher in the eosinophilic CRS group than in the non-eosinophilic CRS group from human nasal polyps. IL-33 induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 induced MUC5B and FOXA3 , and reduces FOXJ mRNA. In conclusion, our present study demonstrated that the direct evidence of IL-33 which lead to increase mucin gene and protein expression, as well as goblet cell hyperplasia. This study provides novel insights into the role of IL-33 on mucus overproduction in eosinophilic inflammation of human airways. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10434666
Volume :
90
Database :
Academic Search Index
Journal :
Cytokine
Publication Type :
Academic Journal
Accession number :
121026212
Full Text :
https://doi.org/10.1016/j.cyto.2016.10.010