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Does alcohol consumption modify the risk of endometrial cancer? A dose-response meta-analysis of prospective studies.

Authors :
Zhou, Quan
Guo, Peng
Li, Hui
Chen, Xiao-dan
Source :
Archives of Gynecology & Obstetrics. Feb2017, Vol. 295 Issue 2, p467-479. 13p. 1 Diagram, 3 Charts, 3 Graphs.
Publication Year :
2017

Abstract

<bold>Background: </bold>Epidemiological studies have provided controversial evidence of an association between alcohol intake and endometrial cancer (EC) risk. The World Cancer Research Fund/American Institute for Cancer Research classifies alcohol as having a "limited-no conclusion" grade of evidence in the Endometrial Cancer 2013 Report (the latest version).<bold>Objective: </bold>The purpose of this meta-analysis is to systematically analyze the effect of alcohol intake on EC risk.<bold>Methods: </bold>We conducted a dose-response meta-analysis of prospective cohort studies identified from the PubMed, Embase, Cochrane Library and China Biological Medicine databases. Categorical and dose-response meta-analyses were conducted to estimate the effects of alcohol on EC risk.<bold>Results: </bold>A total of 10 studies involving 9766 cases and 1,612,798 participants were included in this meta-analysis. Overall, the relative risk(RR) for alcohol intake on EC was 1.04 (95% CI 0.88-1.22). The RRs for alcohol intake from wine, beer, and liquor were 1.10 (95% CI 0.80-1.51), 0.94 (95% CI 0.72-1.22), and 1.04 (95% CI 0.86-1.27), respectively). When alcohol consumption was stratified by drinking level, the RRs for moderate and heavy alcohol intake were 0.95 (95% CI 0.89-1.01) and 1.00 (95% CI 0.88-1.13), respectively. In the subgroup analyses, this association was not modified by other lifestyle factors or the characteristics of the study design and population. No significant associations were detected in the dose-response meta-analyses.<bold>Conclusions: </bold>Alcohol intake is not associated with EC regardless of the beverage choice and alcohol consumption level. More studies are warranted in other populations, such as Asians and Africans. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09320067
Volume :
295
Issue :
2
Database :
Academic Search Index
Journal :
Archives of Gynecology & Obstetrics
Publication Type :
Academic Journal
Accession number :
121014715
Full Text :
https://doi.org/10.1007/s00404-016-4263-y