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Four Matrine-Based Alkaloids with Antiviral Activities against HBV from the Seeds of Sophora alopecuroides.
- Source :
-
Organic Letters . Jan2017, Vol. 19 Issue 2, p424-427. 4p. - Publication Year :
- 2017
-
Abstract
- Four novel matrine-based alkaloids (1-4) were isolated from the seeds of Sophora alopecuroides. Compounds 1 and 2 possess unprecedented 6/6/6/4 and 6/5/6/6 ring systems, respectively, while 3 and 4 are a pair of stereoisomeric matrine-acetophenone alkaloids with an unusual skeleton. Their structures were elucidated by means of spectroscopic methods and single-crystal X-ray diffraction. Hypothetical biogenetic pathways for 1-4 are proposed, and their antiviral activities are also discussed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALKALOIDS
*LEGUME seeds
*SOPHORA alopecuroides
*ANTIVIRAL agents
*HEPATITIS B virus
Subjects
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 19
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 120964755
- Full Text :
- https://doi.org/10.1021/acs.orglett.6b03685