Back to Search
Start Over
Genome-Wide Association between Transcription Factor Expression and Chromatin Accessibility Reveals Regulators of Chromatin Accessibility.
- Source :
-
PLoS Computational Biology . 1/24/2017, Vol. 13 Issue 1, p1-19. 19p. - Publication Year :
- 2017
-
Abstract
- To better understand genome regulation, it is important to uncover the role of transcription factors in the process of chromatin structure establishment and maintenance. Here we present a data-driven approach to systematically characterise transcription factors that are relevant for this process. Our method uses a linear mixed modelling approach to combine datasets of transcription factor binding motif enrichments in open chromatin and gene expression across the same set of cell lines. Applying this approach to the ENCODE dataset, we confirm already known and imply numerous novel transcription factors that play a role in the establishment or maintenance of open chromatin. In particular, our approach rediscovers many factors that have been annotated as pioneer factors. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHROMATIN
*GENE expression
*CELL lines
*TRANSCRIPTION factors
*GENOMES
Subjects
Details
- Language :
- English
- ISSN :
- 1553734X
- Volume :
- 13
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- PLoS Computational Biology
- Publication Type :
- Academic Journal
- Accession number :
- 120932553
- Full Text :
- https://doi.org/10.1371/journal.pcbi.1005311