Efecto de los anti-inflamatorios no esteroideos, ibuprofeno, y meloxicam y del acetaminofen en la sobrevida de la Drosophila melanogaster.

Dysregulation of inflammatory mechanisms are associated to aging and neurodegenerative diseases. Several authors have proposed that genes related to pro-inflammatory effects are involved in aging. In the present study, the effect of long-term treatment with Ibuprofen (IBU), Acethaminophen (ACET) and meloxicam (MEL) was evaluated in Drosophila melanogaster. At the concentrations tested these drugs induced in the mayority of the cases, a decrease of the lifespan in both sexes. These results suggest that adverse effects of these compounds predominate in this animal model. [ABSTRACT FROM AUTHOR]