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Nifedipine increases fetoplacental perfusion.
- Source :
-
Journal of Perinatal Medicine . Jan2017, Vol. 45 Issue 1, p51-55. 5p. 1 Black and White Photograph, 2 Charts. - Publication Year :
- 2017
-
Abstract
- Aim: Our aim is to evaluate the effect of nifedipine on fetoplacental hemodynamic parameters. Methods: A retrospective study was conducted at a tertiary center with 30 patients for whom nifedipine treatment was used as a tocolytic therapy for preterm labor. Initiation of this treatment was at 31.6±2.5 weeks of gestation. We combined the pulse Doppler imaging parameters with grayscale imaging via the Bernoulli theorem, which is called the "continuity equation", to get the fetoplacental perfusion (FPP). Evaluated parameters were the resistance index (RI), the pulsatility index (PI), systole/diastole ratios (S/D), the velocity-time integral of the umbilical artery (VTI), the radius of the umbilical artery, the peak systolic velocity and the mean pressure gradient in the umbilical artery. From these parameters, the FPP was acquired. Results: We found that the RI, the PI and the S/D ratio did not change after treatment with nifedipine. The mean pressure gradient, the VTI and the peak systolic velocity increased after treatment with nifedipine. Nifedipine increases FPP from 166±73.81 beat.cm3/min to 220±83.3 beat.cm3/min. Discussion: Although nifedipine had no effect on the PI, the RI or the S/D, it increased the mean pressure gradient, the VTI and FPP. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD flow measurement
*VASODILATION
*FETAL ultrasonic imaging
*HEMODYNAMICS
*PREMATURE infants
*LONGITUDINAL method
*MATERNAL health services
*MATERNAL-fetal exchange
*NIFEDIPINE
*PERFUSION
*PREGNANT women
*RETROSPECTIVE studies
*DESCRIPTIVE statistics
*UMBILICAL arteries
*FETAL blood vessels
*TERTIARY care
*PHARMACODYNAMICS
*ANATOMY
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 03005577
- Volume :
- 45
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Perinatal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 120714261
- Full Text :
- https://doi.org/10.1515/jpm-2016-0072