Convenient synthesis, antimicrobial evaluation and molecular modeling of some novel quinoline derivatives.

α, β-Unsaturated carbonyl compounds2a, 2b, 3,and4were synthesized by the Knoevenagel condensation between 2-substituted quionoline-3-carboxaldehyde1aand/or1bwith active methylene compounds. In addition, the synthesis of azlactone is achieved starting from1aandN-acetylglycine. Synthesis of pyridine, pyrene, and pyrimidine derivatives6–8were accomplished via one-pot multicomponent reaction of1bwith acetyl acetone, malononitrile, and ammonium acetate; acetophenone, malononitrile, and NaOH; or acetyl acetone and urea in acidic medium. The new synthesized compounds showed good antimicrobial activities. The DFT calculations have been used to predict the electronic properties of the studied compounds. [ABSTRACT FROM PUBLISHER]