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Body mass index, inflammatory biomarkers and neurocognitive impairment in HIV-infected persons.
- Source :
-
Psychology, Health & Medicine . Mar2017, Vol. 22 Issue 3, p289-302. 14p. - Publication Year :
- 2017
-
Abstract
- To determine the relationships among body mass index (BMI), and HIV-associated neurocognitive impairment and the potential mediating effects of inflammatory cytokines. Among the HIV-infected individuals (N = 90) included in this study, obesity was associated with slower processing speed (? = ?.229, standard error (SE) = 2.15,p = .033), compared to participants with a normal BMI, after controlling for psychosocial and HIV clinical factors. Serum concentrations of the interleukin-16 (IL-16) cytokine were significantly associated with slowed processing speed (? = ?.235, SE = 1.62,p = .033) but did not mediate the relationship between obesity and processing speed These findings suggest that obesity may contribute to cognitive processing speed deficits in HIV-infected adults. Elevated concentrations of IL-16 are also associated with slowing, though the results suggest that obesity and IL-16 may exert independent effects. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *HIV infection complications
*ACADEMIC medical centers
*ANALYSIS of variance
*BIOMARKERS
*CHI-squared test
*COGNITION disorders
*ENZYME-linked immunosorbent assay
*FISHER exact test
*IMMUNOENZYME technique
*INFLAMMATION
*INTERLEUKINS
*NEUROPSYCHOLOGICAL tests
*OBESITY
*REGRESSION analysis
*RESEARCH funding
*T-test (Statistics)
*WESTERN immunoblotting
*BODY mass index
*DATA analysis software
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 13548506
- Volume :
- 22
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Psychology, Health & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 120686784
- Full Text :
- https://doi.org/10.1080/13548506.2016.1199887