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5-HT7 receptor-mediated fear conditioning and possible involvement of extracellular signal-regulated kinase.
- Source :
-
Neuroscience Letters . Jan2017, Vol. 638, p69-75. 7p. - Publication Year :
- 2017
-
Abstract
- Fear conditioning is a valuable behavioral paradigm for studying the neural basis of emotional learning and memory. The present study examined the involvement of extracellular signal-regulated kinase 1/2 (ERK) signaling on the serotonin (5-HT) 7 receptor-mediated fear conditioning. Conditioning was performed in a trial in which a tone was followed by an electrical foot-shock. Context- and tone-dependent fear were examined in tests conducted 24 and 48 h after conditioning, respectively. The selective 5-HT 7 receptor antagonist 2 a -[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)butyl]-2 a ,3,4,-tetrahydrobenzo( c , d )indol-2-(1 H )-one (DR4004) (5 mg/kg), when administered intraperitoneally (i.p.) immediately after conditioning, caused a significant decrease in both context- and tone-dependent fear responses (freezing behavior). A significant increase in ERK activity was observed in the amygdala of mice that displayed context- or tone-dependent fear responses, and these changes were also inhibited by the administration of DR4004 (5 mg/kg, i.p.) immediately after conditioning. In contrast, the increase in hippocampal ERK activity in mice that displayed context-dependent fear responses was further enhanced by the administration of DR4004 (5 mg/kg, i.p.). These results suggest that 5-HT 7 receptor-mediated ERK signaling may play a significant role in the processes of emotional learning and memory. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 638
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 120672269
- Full Text :
- https://doi.org/10.1016/j.neulet.2016.11.065