Back to Search
Start Over
Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages.
- Source :
-
OncoImmunology . 2016, Vol. 5 Issue 12, p1-1. 1p. - Publication Year :
- 2016
-
Abstract
- Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment in non-medullary thyroid cancer (TC), the most common endocrine malignancy. However, little is known regarding the regulation of their function in TC. Transcriptome analysis in a model of TC-induced macrophages identified increased inflammatory characteristics and rewiring of cell metabolism as key functional changes. This functional reprogramming was partly mediated by TC-derived lactate that induced upregulation of cytokine production through an AKT1/mTOR-dependent increase in aerobic glycolysis. This led to epigenetic modifications at the level of histone methylation, and subsequently long-term functional changes. Immunohistochemistry assessment validated the increase in glycolysis enzymes and lactate receptor in TAMs in tissue samples from patients with TC. In conclusion, Akt/mTOR-dependent glycolysis mediates TC-induced reprogramming of TAMs and inflammation, and this may represent a novel therapeutic target in TC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MACROPHAGES
*GENOTYPES
Subjects
Details
- Language :
- English
- ISSN :
- 21624011
- Volume :
- 5
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- OncoImmunology
- Publication Type :
- Academic Journal
- Accession number :
- 120643796
- Full Text :
- https://doi.org/10.1080/2162402X.2016.1229725