Back to Search
Start Over
A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection.
- Source :
-
Microbes & Infection . Jan2017, Vol. 19 Issue 1, p69-74. 6p. - Publication Year :
- 2017
-
Abstract
- We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENETIC polymorphisms
*AMINO acids
*MUCINS
*T cells
*IMMUNOGLOBULINS
*HIV infections
Subjects
Details
- Language :
- English
- ISSN :
- 12864579
- Volume :
- 19
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Microbes & Infection
- Publication Type :
- Academic Journal
- Accession number :
- 120543657
- Full Text :
- https://doi.org/10.1016/j.micinf.2016.09.005