心脏肌球蛋白结合蛋白 C 的生物信息学分析.

The MYBPC3gene mutations can cause hypertrophic cardiomyopathy (HCM). To analyze the biologycal information of MYBPC3gene and its coding protein. Bioinformatics approaches are applied to analyze mutant sites, hereditary conservation, chemical properties, space structure, and protein interaction networks of cMyBP-C protein. The cMyBP-C protein is comprised of 1 274 amino acid residues which belong to the immunoglobulin super family. It is a hydrophilic unstable protein without transmembrane region. The main secondary structure elements are random coil, and it contained eight immunoglobulin domains and three fibronectin type 3 domains. Interactive proteins with cMyBP-C are mainly its phosphokinase and sarcomere components. We analyze the insightful information of MYBPC3gene and its protein providing certain theoretical basis for the research of gene function of MYBPC3and its role in the formation and development of HCM. [ABSTRACT FROM AUTHOR]