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Effect of β-alanine and the solvent composition on the solubility of solvate of calcium d-pantothenate containing four molecules of methanol and one molecule of water (D-PC·4MeOH·1H2O).
- Source :
-
Journal of Chemical Thermodynamics . Mar2017, Vol. 106, p36-46. 11p. - Publication Year :
- 2017
-
Abstract
- The solubility of calcium d -pantothenate in (water + methanol) mixtures and the effect of β -alanine on the solubility of calcium d -pantothenate in a constant mole ratio of methanol and water was measured from 263.15 K to 303.15 K by the HPLC analysis method ( P = 0.1 MPa). The solubility of calcium d -pantothenate increased with increasing temperature in all the mixtures at constant composition. Besides, it also increased with mole fraction of water in (water + methanol) mixtures at a constant temperature. Additionally, the solubility of calcium d -pantothenate was enhanced by β -alanine at a given temperature. The experimental solubility in (water + methanol) mixtures was correlated by the modified Apelblat equation, the ternary NRTL equation and Solubility-Polarity Model. The Apelblat equation, the quaternary NRTL equation and the Cohn equation were adopted to correlate the experimental solubility in the (water + methanol + β -alanine) mixtures. Worthwhile, the quaternary NRTL equation was first applied to correlating the quaternary solid-liquid equilibrium. It turned out that all the selected models give good performance on solubility prediction. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219614
- Volume :
- 106
- Database :
- Academic Search Index
- Journal :
- Journal of Chemical Thermodynamics
- Publication Type :
- Academic Journal
- Accession number :
- 120446199
- Full Text :
- https://doi.org/10.1016/j.jct.2016.11.011