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Peri-sciatic administration of indomethacin early after nerve injury can attenuate the development of tactile allodynia in a rat model of L5 single spinal nerve injury
- Source :
-
Neuroscience Letters . Feb2004, Vol. 356 Issue 1, p37. 4p. - Publication Year :
- 2004
-
Abstract
- To clarify the role of cyclooxygenase in the peripheral nerve on the development of neuropathic pain, we investigated the effects of peri-sciatic administration of indomethacin on the development of allodynia in a model of L5 single spinal nerve injury. Peri-sciatic administration of indomethacin (1 mg/kg) was performed 3, 24, or 72 h after nerve injury (<f>n=6</f>/each). In rats with indomethacin 3 or 24 h after nerve injury, ipsi-lateral paw withdrawal thresholds 7–35 days after nerve injury were significantly higher compared with those in the control group (<f>n=6</f>: without peri-sciatic treatment) (<f>P<0.05</f>). However, such efficacy was no longer apparent when indomethacin was administered 72 h after nerve injury. These results suggest that peri-sciatic administration of indomethacin early (less than 24 h) after nerve injury can attenuate the development of allodynia. [Copyright &y& Elsevier]
- Subjects :
- *CYCLOOXYGENASES
*NEUROLOGICAL disorders
*INDOMETHACIN
*ALLODYNIA
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 356
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 12043685
- Full Text :
- https://doi.org/10.1016/j.neulet.2003.11.017