Back to Search Start Over

Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines.

Authors :
Bonazaba Milandou, Longin Justin Clair
Carreyre, Hélène
Alazet, Sébastien
Greco, Gino
Martin‐Mingot, Agnès
Nkounkou Loumpangou, Célestine
Ouamba, Jean‐Maurille
Bouazza, Fodil
Billard, Thierry
Thibaudeau, Sébastien
Source :
Angewandte Chemie International Edition. 1/2/2017, Vol. 56 Issue 1, p169-172. 4p.
Publication Year :
2017

Abstract

Upon activation under superacid conditions, functionalized tailor-made N-SCF3 sulfenamides served as reagents for the trifluoromethylthiolation of aromatic amines. This method has a broad substrate scope and can be used for the late-stage functionalization of complex molecules such as alkaloids or steroids. Mechanistic studies based on in situ low-temperature NMR spectroscopy revealed the involvement of dicationic superelectrophilic intermediates. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14337851
Volume :
56
Issue :
1
Database :
Academic Search Index
Journal :
Angewandte Chemie International Edition
Publication Type :
Academic Journal
Accession number :
120413169
Full Text :
https://doi.org/10.1002/anie.201609574