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Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines.
- Source :
-
Angewandte Chemie International Edition . 1/2/2017, Vol. 56 Issue 1, p169-172. 4p. - Publication Year :
- 2017
-
Abstract
- Upon activation under superacid conditions, functionalized tailor-made N-SCF3 sulfenamides served as reagents for the trifluoromethylthiolation of aromatic amines. This method has a broad substrate scope and can be used for the late-stage functionalization of complex molecules such as alkaloids or steroids. Mechanistic studies based on in situ low-temperature NMR spectroscopy revealed the involvement of dicationic superelectrophilic intermediates. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 56
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 120413169
- Full Text :
- https://doi.org/10.1002/anie.201609574