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Novel anti-tumour barringenol-like triterpenoids from the husks of Xanthoceras sorbifolia Bunge and their three dimensional quantitative structure activity relationships analysis.
- Source :
-
Fitoterapia . Jan2017, Vol. 116, p51-60. 10p. - Publication Year :
- 2017
-
Abstract
- The high edible oil content of Xanthoceras sorbifolia Bunge seeds contributes to its economic value. In this study, we analysed the barrigenol-like triterpenoids derived from X . sorbifolia husks. We also identified anti-tumour agents that could enhance the health benefits and medicinal value of X . sorbifolia . We isolated 10 barrigenol triterpenoids, including six new compounds ( 1 – 6 ) and four known compounds ( 7 – 10 ). New compounds 3 and 5 showed significant inhibitory activity against the proliferation of three human tumour cell lines, namely, HepG2, HCT-116 and U87-MG. We determined the relationship between the structures and inhibitory activity of 25 barrigenol triterpenoids and 15 penta-cyclic triterpenoids through analysis of three-dimensional quantitative structure activity relationships (3D-QSAR). The isolation of novel barrigenol derivatives with anti-tumour activity from X . sorbifolia implied that husks of this plant may be a good source of anti-tumour agents. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 116
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 120408994
- Full Text :
- https://doi.org/10.1016/j.fitote.2016.11.002