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DPP-4 Inhibitor Treatment in Chinese Type 2 Diabetes Patients: A Meta-Analysis.
- Source :
-
Diabetes Technology & Therapeutics . Dec2016, Vol. 18 Issue 12, p784-793. 10p. - Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>The aim of this meta-analysis was to assess the comprehensive clinical efficacy of dipeptidyl peptidase-IV (DPP-4) inhibitors in Chinese type 2 diabetes patients and to evaluate whether there is a different response to treatment with different kinds of DPP-4 inhibitors in those patients.<bold>Methods: </bold>Databases were systematically searched, and qualifying clinical studies of Chinese type 2 diabetes patients were included.<bold>Results: </bold>A total of 30 studies were included. Treatment with saxagliptin resulted in a significantly greater change from baseline in HbA1c levels (weighted mean difference [WMD], -1.28%; 95% CI, -1.37% to -1.19%); treatment with sitagliptin led to a significantly greater change from baseline (WMD, -1.17%; 95% CI, -1.46% to -0.89%); treatment with vildagliptin was associated with a significantly greater change in HbA1c levels (WMD, -0.77%; 95% CI, -0.88% to -0.65%); treatment with linagliptin led to a significantly greater change (WMD, -0.84%; 95% CI, -0.92% to -0.75%); and treatment with alogliptin also led to a significantly greater change (WMD, -0.91%; 95% CI, -1.48% to -0.33%). In terms of body weight, treatment with saxagliptin was associated with no significant decreases in Chinese type 2 diabetes mellitus (T2DM) patients (WMD, -0.17 kg, 95% CI, -4.26 to 3.92 kg). Treatment with sitagliptin and linagliptin was also associated with no significant changes in body weight (WMD, 0.16 and 0.11 kg, respectively, P > 0.05).<bold>Conclusions: </bold>In Chinese type 2 diabetes patients, the efficacy of glucose control in all five kinds of DPP-4 inhibitor treatments was well confirmed, and no significant change in body weight was found. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15209156
- Volume :
- 18
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Diabetes Technology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 120354634
- Full Text :
- https://doi.org/10.1089/dia.2016.0302