Urticaria and angioedema during insemination with fluid containing bovine serum albumin.

Bovine serum albumin (BSA) is often present in the dilution fluid added to semen for artificial insemination. A case of serum sickness due to BSA after a first in vitro fertilization has been reported, in addition to an IgE-mediated reaction to BSA in a case of anaphylaxis due to infusion of autologous bone marrow. A 36-year-old nonatopic female developed generalized urticaria and angioedema 30 minutes after her 1st course of artificial insemination. The fluid inseminated contained her husbands semen diluted in a solution of antibiotics and BSA.