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Effects of Nano-biphasic Calcium Phosphate Composite on Bioactivity and Osteoblast Cell Behavior in Tissue Engineering Applications.
- Source :
-
Journal of Medical Signals & Sensors . Oct-Dec2016, Vol. 6 Issue 4, p237-242. 6p. - Publication Year :
- 2016
-
Abstract
- In this paper, preparation, bioactivity, and osteoblast cell behavior of cortical bone derived nano-biphasic calcium phosphate (nano-BCP) are presented. The calcined bovine bone samples with the addition of di-ammonium hydrogen phosphate were heated at 700°C for 100min, and thus nano-BCP with the composition of 63/37 hydroxyapatite (HA)/β-tricalcium phosphate (β-TCP) was produced. Scanning electron microscopy (SEM) images, energy dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD) analysis of immersed samples in simulated body fluid (SBF) solution showed that a uniform layer was formed on the surface after 7 days with the chemical composition of HA. The results indicated that the nano-BCP sample developed excellent bioactivity after 28 days. The nano-BCP samples showed better cell proliferation compared to pure HA samples. After 7 days in cell culture, the prepared nano-BCP (HA/β-TCP) exhibited the maximum proliferation of the MG-63 osteoblast cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OSTEOBLASTS
*COMPACT bone
*CALCIUM phosphate
Subjects
Details
- Language :
- English
- ISSN :
- 22287477
- Volume :
- 6
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Medical Signals & Sensors
- Publication Type :
- Academic Journal
- Accession number :
- 120294217
- Full Text :
- https://doi.org/10.4103/2228-7477.195092