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Mitochondria-targeting “Nanoheater” for enhanced photothermal/chemo-therapy.

Authors :
Chen, Si
Lei, Qi
Qiu, Wen-Xiu
Liu, Li-Han
Zheng, Di-Wei
Fan, Jin-Xuan
Rong, Lei
Sun, Yun-Xia
Zhang, Xian-Zheng
Source :
Biomaterials. Feb2017, Vol. 117, p92-104. 13p.
Publication Year :
2017

Abstract

In this work, mitochondria-targeting gold nanostar (AuNS) and anticarcinogen DOX were co-encapsulated in hyaluronic acid (HA) protective shell for tumor-targeting synergistic photothermal/chemo-therapy. Cationic peptide R 8 and mitochondria-targeting pro-apoptotic peptide TPP-KLA were co-decorated on AuNS to form AuNS-pep via Au-S bonds. Then, electronegative HA was further coated on the surface via electrostatic interaction for cancer cell targeting. During the coating process, DOX was also introduced via electrostatic interaction to obtain a versatile nanoplatform AuNS-pep/DOX@HA. It was found that the nanoplatform could be internalized into tumor cells via CD44 receptor-mediated recognition. Followed digestion by hyaluronidase (HAase), the therapeutic nanoplatform was able to release DOX for chemotherapy and mitochondria-targeting nanoheater AuNS-pep for near infrared (NIR) light triggered subcellular photothermal therapy (PTT). This tumor-targeting nanoplatform AuNS-pep/DOX@HA displayed prominent non-resistant or resistant tumor inhibition both in vitro and in vivo . [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01429612
Volume :
117
Database :
Academic Search Index
Journal :
Biomaterials
Publication Type :
Academic Journal
Accession number :
120276981
Full Text :
https://doi.org/10.1016/j.biomaterials.2016.11.056