Metal-based ethanolamine-derived compounds: a note on their synthesis, characterization and bioactivity.

Metal-based ethanolamines,(L1)–(L4)coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals in 1:2 (metal:ligand) molar ratio to produce new compounds have been reported. These compounds were screened for their bactericidal/fungicidal activity against a number of bacterial (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureusandBacillus subtilis) and fungal strains (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solaniandCandida glabrata) alongside against a shrimp species known asArtemia salina. The screening results indicated that metal complexes have significantly higher activity than uncomplexed ligands against one or more bacterial/fungal species due to chelation. The ligand (L4) displayed good bacterial and fungal activity as compared to other ligands. The antibacterial results revealed that the Zn(II) complex(16)of (L4) was found to be the most active complex and Co(II) complex(14)of the same ligand (L4), demonstrated the highest antifungal activity. [ABSTRACT FROM PUBLISHER]