Phosphorylation of aminomalonates.

Authors :: Egorova, A.
Viktorov, N.
Lyamenkova, D.
Svintsitskaya, N.
Garabadziu, A.
Dogadina, A.
Source :: Russian Journal of General Chemistry. Nov2016, Vol. 86 Issue 11, p2446-2453. 8p.
Publication Year :: 2016
Abstract: The reactions of chloroethynylphosphonates with aromatic secondary aminomalonates occur as classic nucleophilic substitution of chlorine atom at the sp-hybridizied carbon atom to form new phosphorylated 2-arylaminomalonates, diethyl esters of 2-(diethoxyphosphorylethynyl)-2-arylaminomalonic acids. Nonobservance of chemo- and regioselectivity was revealed when using cyclohexyl- and benzylaminomalonates. [ABSTRACT FROM AUTHOR]