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Latent Expression of the Epstein-Barr Virus (EBV)-Encoded Major Histocompatibility Complex Class I TAP Inhibitor, BNLF2a, in EBV-Positive Gastric Carcinomas.
- Source :
-
Journal of Virology . Oct2015, Vol. 89 Issue 20, p10110-10114. 5p. - Publication Year :
- 2015
-
Abstract
- The Epstein-Barr virus (EBV) BNLF2a gene product provides immune evasion properties to infected cells through inhibition of transporter associated with antigen processing (TAP)-mediated transport of antigen peptides. Although BNLF2a is considered to be a lytic gene, we demonstrate that it is expressed in nearly half of the EBV-associated gastric carcinomas analyzed. Further, we show that BNLF2a expression is dissociated from lytic gene expression. BNLF2a is therefore expressed in this latency setting, potentially helping protect the infected tumor cells from immunosurveillance. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EPSTEIN-Barr virus
*MAJOR histocompatibility complex
*STOMACH cancer
*GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 89
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 120255597
- Full Text :
- https://doi.org/10.1128/JVI.01110-15