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Two-Dimensional Fully Conjugated Polymeric Photosensitizers for Advanced Photodynamic Therapy.
- Source :
-
Chemistry of Materials . Dec2016, Vol. 28 Issue 23, p8651-8658. 8p. - Publication Year :
- 2016
-
Abstract
- Photodynamic therapy (PDT) is attractive for treatment of various cancers, with a high selectivity, minimal long-term effect, and excellent cosmetic appeal. Well water-dispersive photosensitizers with strong optical absorption within the tissue transparency window (700-1000 nm) are needed for efficient PDT. However, clinically used PDT agents based on oligomeric porphyrin units (e.g., protoporphyrin IX) are effective at 532 nm irradiation only. Herein, we synthesized a two-dimensional covalent organic polymer (COP) containing fully conjugated multiple porphyrin macrocycles with sulfonic acid side groups. The resultant COP-P-SO3H is well water-dispersive, showing strong optical absorption within the desired therapeutic window and a high quantum yield of reactive oxygen species, especially singlet oxygen (¹O2), for efficiently killing tumor cells upon near-infrared light irradiation. Our first-principles calculations revealed that the observed high yield ¹O2 resulted from the unique side-on parallel diatomic adsorption (Yeager mode) of triplet oxygen molecules on the highly conjugated porphyrin rings in the photoexcited COP-P-SO3H. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08974756
- Volume :
- 28
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Chemistry of Materials
- Publication Type :
- Academic Journal
- Accession number :
- 120248126
- Full Text :
- https://doi.org/10.1021/acs.chemmater.6b03619