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Two-Dimensional Fully Conjugated Polymeric Photosensitizers for Advanced Photodynamic Therapy.

Authors :
Zhonghua Xiang
Lin Zhu
Lei Qi
Lu Yan
Yuhua Xue
Dan Wang
Jian-Feng Chen
Liming Dai
Source :
Chemistry of Materials. Dec2016, Vol. 28 Issue 23, p8651-8658. 8p.
Publication Year :
2016

Abstract

Photodynamic therapy (PDT) is attractive for treatment of various cancers, with a high selectivity, minimal long-term effect, and excellent cosmetic appeal. Well water-dispersive photosensitizers with strong optical absorption within the tissue transparency window (700-1000 nm) are needed for efficient PDT. However, clinically used PDT agents based on oligomeric porphyrin units (e.g., protoporphyrin IX) are effective at 532 nm irradiation only. Herein, we synthesized a two-dimensional covalent organic polymer (COP) containing fully conjugated multiple porphyrin macrocycles with sulfonic acid side groups. The resultant COP-P-SO3H is well water-dispersive, showing strong optical absorption within the desired therapeutic window and a high quantum yield of reactive oxygen species, especially singlet oxygen (¹O2), for efficiently killing tumor cells upon near-infrared light irradiation. Our first-principles calculations revealed that the observed high yield ¹O2 resulted from the unique side-on parallel diatomic adsorption (Yeager mode) of triplet oxygen molecules on the highly conjugated porphyrin rings in the photoexcited COP-P-SO3H. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08974756
Volume :
28
Issue :
23
Database :
Academic Search Index
Journal :
Chemistry of Materials
Publication Type :
Academic Journal
Accession number :
120248126
Full Text :
https://doi.org/10.1021/acs.chemmater.6b03619