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Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population.
- Source :
-
Journal of Clinical Research in Pediatric Endocrinology . Dec2016, p405-410. 6p. - Publication Year :
- 2016
-
Abstract
- Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting 5-7% of reproductive age women worldwide. The aim of our study was to explore the PCOS-related single nucleotide polymorphism (SNP) associations between common genetic variants and PCOS risk in a Han Chinese women population. Methods: In this case-control study, 285 Chinese Han women aged 28.50±6.858 years with PCOS and 299 controls of a mean age of 32.66±7.018 years were compared. We selected recently published genome-wide association studies (GWAS) which identified several genetic loci in PCOS. All the SNPs were genotyped by Sequenom Mass-ARRAY technology. Associations between the gene and the risk of PCOS were tested using various genetic models by Statistical Package for the Social Sciences and Plink. Results: We found that rs705702 in the RAB5B/SUOX was associated with PCOS (odds ratio=1.42; 95% confidence interval=1.08-1.87, p=0.011) and increased the PCOS risk. The genotypic model analysis also showed that rs705702 was associated with PCOS risk. Conclusion: Our results suggest that SNPs rs705702 in gene RAB5B/SUOX was associated with PCOS in Han Chinese women. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13085727
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Research in Pediatric Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 120237861
- Full Text :
- https://doi.org/10.4274/jcrpe.2784