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Low vitamin D is associated with negative and depressive symptoms in psychotic disorders.
- Source :
-
Schizophrenia Research . Dec2016, Vol. 178 Issue 1-3, p44-49. 6p. - Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>There are indications that low S-25(OH)D is associated with increased disease severity in psychotic disorder. Our first aim was to investigate the relations between low S-25(OH)D and positive, negative and depressive symptoms. Our second aim was to explore if associations between S-25(OH)D and symptoms were influenced by levels of inflammatory markers.<bold>Methods: </bold>Participants (N=358) with a medical history of one or more psychotic episodes were recruited. Current symptomatology was assessed by The Structured Interview for the Positive and Negative Syndrome Scaleanalyzed by a five-factor model. The Calgary Depression Scale for Schizophrenia was used to assess depression and suicidal ideation. Blood samples were analyzed for S-25(OH)D, CRP, sTNF-R1, IL-Ra and OPG. We performed bivariate correlations and multiple regression models to evaluate the effect of S-25(OH)D on the outcomes.<bold>Results: </bold>Low S-25(OH)D was significantly associated with negative symptoms (adjusted R2=0.113, F(6,357)=8.58, p<0.001) and with depression (adjusted R2=0.045, F(4,357)=5.233, p<0.001) when adjusting for possible confounding factors (i.e. gender, education, diagnose, hospitalization status, ethnicity, season and thyroid status). CRP was correlated with both S-25(OH)D (rho=-0.13, p=0.02) and negative symptoms (rho=0.14, p=0.01), but did not act as a mediator. The correlations between S-25(OH)D and the inflammatory markers sTNF-R1, IL-Ra and OPG were not significant.<bold>Conclusion: </bold>There is a strong association between low S-25(OH)D and higher negative and depressive symptoms in psychotic disorders. Randomized controlled trials should be performed to investigate the effect of vitamin D supplementation as adjuvant treatment strategy in patients with prominent negative or depressive symptoms. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PSYCHOSES
*CALCIUM regulating hormones
*VITAMIN D
*DISEASES
*BLOOD pressure
*INFLAMMATION
*COMPARATIVE studies
*MENTAL depression
*RESEARCH methodology
*MEDICAL cooperation
*MENTAL status examination
*PSYCHOLOGY
*REGRESSION analysis
*RESEARCH
*SCHIZOPHRENIA
*EVALUATION research
*VITAMIN D deficiency
*SUICIDAL ideation
*CROSS-sectional method
*DISEASE complications
*PSYCHOLOGICAL factors
Subjects
Details
- Language :
- English
- ISSN :
- 09209964
- Volume :
- 178
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- Schizophrenia Research
- Publication Type :
- Academic Journal
- Accession number :
- 120142982
- Full Text :
- https://doi.org/10.1016/j.schres.2016.08.024