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A novel N-doped carbon nanotube fiber for selective and reliable electrochemical determination of ascorbic acid in rat brain microdialysates.
- Source :
-
Journal of Electroanalytical Chemistry . Nov2016, Vol. 781, p278-283. 6p. - Publication Year :
- 2016
-
Abstract
- Selective and reliable method is of great importance for in vivo analysis in the complicated brain. In this work, we developed a new approach for detection of ascorbic acid (AA) based on a new nitrogen-doped nanotube fiber (NCNF) microelectrode. After electrochemical pre-treatment, the NCNF microelectrode (e-NCNF) demonstrated high electrocatalytic capability for AA oxidation with a low working potential, 0 V, resulting in high selectivity for detection of AA level against other biological species in brain, as well as producing high sensitivity. Moreover, the e-NCNF was directly assembled by carbon nanotube bundles, free from the post-modification, thus showing high reproducibility, in which the deviation of anodic current intensity of six electrodes prepared with same method did not exceed 4% (RSD, n = 6). Based on the remarkable analytical performance, the e-NCNF with good biocompatibility was successfully applied to determine the AA level as 134 ± 7 mM, in rat brain microdialysates. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15726657
- Volume :
- 781
- Database :
- Academic Search Index
- Journal :
- Journal of Electroanalytical Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 120047675
- Full Text :
- https://doi.org/10.1016/j.jelechem.2016.10.027