Effect of a surgical aortocaval fistula on monocrotaline-induced pulmonary hypertension.

OBJECTIVEIncreased pulmonary blood flow is believed to contribute to the development of pulmonary hypertension. We investigated the effect of overcirculation via an aortocaval fistula, on the development of monocrotaline-induced pulmonary hypertension in rats. Monocrotaline was administered 1 wk after the creation of an aortocaval fistula.DESIGNRandomized, controlled study.SETTINGResearch laboratory of an academic institution.SUBJECTSMale Sprague-Dawley rats.INTERVENTIONSOvercirculation was induced by pneumonectomy and by surgical creation of aortocaval fistula. Pulmonary artery hypertension was induced by administration of monocrotaline.MEASUREMENTS AND MAIN RESULTSAortic blood flow, Pao2, and pulmonary arterial pressure were measured 4 wks later. A blinded investigator quantified pulmonary arterial neointimal formation in small pulmonary arteries. Compared with animals that received monocrotaline and/or underwent pneumonectomy but did not undergo aortocaval fistula, the presence of a surgical aortocaval fistula was associated with increased aortic blood flow (p < .001), increased Pao2 (p < .001), and lower mean pulmonary arterial pressure (p < .001). In addition, rats with aortocaval fistula had less pulmonary arterial neointimal formation than matched animals without an aortocaval fistula (p = .034).CONCLUSIONSThe presence of a surgical aortocaval fistula attenuates, rather than worsens, the development of monocrotaline-induced pulmonary hypertension in rats. [ABSTRACT FROM AUTHOR]