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Research cardiac magnetic resonance imaging in end stage renal disease - incidence, significance and implications of unexpected incidental findings.
- Source :
-
European Radiology . Jan2017, Vol. 27 Issue 1, p315-324. 10p. 3 Black and White Photographs, 1 Diagram, 5 Charts, 1 Graph. - Publication Year :
- 2017
-
Abstract
- <bold>Objectives: </bold>Left ventricular mass (LVM) at cardiac magnetic resonance imaging (CMR) is a frequent end point in clinical trials in nephrology. Trial participants with end stage renal disease (ESRD) may have a greater frequency of incidental findings (IF). We retrospectively investigated prevalence of IF in previous research CMR and reviewed their subsequent impact on participants.<bold>Methods: </bold>Between 2002 and 2006, 161 ESRD patients underwent CMR in a transplant assessment study. Images were used to assess LV mass and function. In the current study a radiologist reviewed the scans for IF. Review of patient records determined the subsequent clinical significance of IF.<bold>Results: </bold>There were 150 IF in 95 study participants. Eighty-four (56 %) were new diagnoses. One hundred and two were non-cardiac. Fifteen were suspicious of malignancy. There was a clinically significant IF for 14.9 % of the participants. In six cases earlier identification of an IF may have improved quality of life or survival.<bold>Conclusions: </bold>Without radiology support clinically important IF may be missed on CMR. Patients undergoing CMR in trials should be counselled about the frequency and implications of IF. Patients with ESRD have a higher prevalence of IF than reported in other populations. Nephrology studies require mechanisms for radiologist reporting and strategies for dealing with IF.<bold>Key Points: </bold>• Incidental findings on research cardiac magnetic resonance imaging can have significant consequences. • We considered incidental findings in historical renal cardiac resonance imaging clinical trials. • Incidental findings are common and important in the chronic kidney disease population. • Without radiology support, clinically significant incidental findings may be missed on imaging. • Study protocols, approvals and consent processes should take account of possible findings. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KIDNEY disease diagnosis
*MAGNETIC resonance imaging
*KIDNEY diseases
*LEFT ventricular hypertrophy
*CHRONIC kidney failure
*PATIENTS
*HEART disease complications
*DIAGNOSIS
*HEART
*HEART diseases
*MYOCARDIUM
*DISEASE incidence
*DISEASE prevalence
*RETROSPECTIVE studies
CHRONIC kidney failure complications
Subjects
Details
- Language :
- English
- ISSN :
- 09387994
- Volume :
- 27
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- European Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 119807681
- Full Text :
- https://doi.org/10.1007/s00330-016-4288-4