Back to Search
Start Over
Synthesis and characterization of a new alkyne functionalized bis(pyrazolyl)methane ligand and of its Pd(II) complexes: Evaluation of their in vitro cytotoxic activity.
- Source :
-
Inorganica Chimica Acta . Jan2017 Part 2, Vol. 455, p677-682. 6p. - Publication Year :
- 2017
-
Abstract
- A novel bis(pyrazolyl)methane ligand bearing alkyne substituents ( C C t Bu) in the C-4 position of the pyrazole rings has been synthesized together with its Pd(II) dichloride and diacetate complexes. Both the Pd(II) complexes are monomeric species stable in the solid state and in organic solution. The crystal structure of the Pd(II) dichloride complex displays a slightly distorted square-planar geometry and the molecules tend to form dimers associated through π–π stacking interactions between the pyrazolyl rings. The in vitro antitumor activities of the free ligand and of its corresponding Pd(II) complexes toward some human cancer cell lines, such as HeLa, SHSY-5Y and K562, have shown to be lower than cisplatin but with a better response in comparison to their parent free ligand. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00201693
- Volume :
- 455
- Database :
- Academic Search Index
- Journal :
- Inorganica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 119775037
- Full Text :
- https://doi.org/10.1016/j.ica.2016.04.032