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Digestion-resistant maltodextrin effects on colonic transit time and stool weight: a randomized controlled clinical study.
- Source :
-
European Journal of Nutrition . Dec2016, Vol. 55 Issue 8, p2389-2397. 9p. 1 Diagram, 3 Charts. - Publication Year :
- 2016
-
Abstract
- Purpose: Increased awareness of the importance of dietary fibre has led to increased interest in 'functional' fibre components like digestion-resistant maltodextrin (RMD). This randomized, placebo-controlled, double-blind study assessed the effects of RMD in the colonic transit time (CTT) and defecation characteristics (frequency, stool volume and consistency). Methods: Sixty-six healthy adult volunteers (32 men) who did not have a daily defecation habit had a 7-day run-in period before the 21-day intervention period with RMD or placebo. CTT and segmental CTT (SCTT) were assessed by a single abdominal X-ray film taken at the end of both periods after radiopaque marker ingestion. Defecation characteristics and intestinal functions were also assessed, which were self-reported by patients. Intragroup comparisons were evaluated by Student's paired t test, Bonferroni test and Chi-square test, while time comparisons by analysis of variance (ANOVA) and time-by-treatment interaction by repeated-measures ANOVA. Results: Fifty-seven subjects were assessed for CTT (placebo, n = 28; RMD, n = 29). In the RMD group, the total CTT, left SCTT and rectosigmoidal SCTT decreased significantly compared to baseline ( p < 0.01 each; −13.3, −4.7, −8.7 h, respectively). Significant differences between groups were observed in total CTT and left SCTT. Significant time-by-treatment interaction was observed in the RMD group for stool volume ( p = 0.014), increasing 56 % compared to baseline ( p < 0.01), while remained unchanged in the placebo group. Stool consistency was improved only in the RMD group ( p < 0.01). No adverse effects related to study products were observed. Conclusions: The results show that RMD improved CTT, stool volume, stool consistency and some intestinal functions in a healthy population. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FECES
*ABDOMINAL radiography
*ANALYSIS of covariance
*ANALYSIS of variance
*CHI-squared test
*CONFIDENCE intervals
*DEFECATION
*DIETARY fiber
*GASTROINTESTINAL motility
*NUTRITIONAL assessment
*PROBABILITY theory
*QUESTIONNAIRES
*RESEARCH funding
*STATISTICAL sampling
*SELF-evaluation
*STATISTICS
*T-test (Statistics)
*TIME
*STATISTICAL power analysis
*DATA analysis
*STATISTICAL significance
*BODY mass index
*RANDOMIZED controlled trials
*PRE-tests & post-tests
*REPEATED measures design
*BLIND experiment
*FOOD diaries
*DATA analysis software
*DESCRIPTIVE statistics
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 55
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 119755058
- Full Text :
- https://doi.org/10.1007/s00394-015-1045-4