糖尿病胃动力障碍大鼠胃窦平滑肌中 PDE2 和 PDE3 蛋白表达变化.

In order to observe the changes of PDE2 and PDE3 in gastric smooth muscle of diabetic gastroparesis rats, rat model of diabetes mellitus was induced by injected streptozotocin (STZ). To record gastric smooth muscle contraction of diabetes rat with multichannel physiology signal recording system. Diabetes rats with gastric smooth muscle contraction indiscriminate were identified as diabetic gastroparesis model. Then to observe content of PDE2 and PDE3 in diabetic gastroparesis rats gastric smooth muscle by immunohistochemistry. Compared with control group rats, PDE2 content in gastroparesis rat gastric smooth muscle was not significantly different, but PDE3 content increased significantly (P<0. 05). Thus, Gastroparesis of diabetes rats may be correlated with PDE3 down-regulation in gastric smooth muscle, and cGMP-PDE3 signal system may be involved in the pathogenesis and development of diabetic gastropathy of gastroparesis. [ABSTRACT FROM AUTHOR]