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Diffusion imaging of cerebral diaschisis in childhood arterial ischemic stroke.
- Source :
-
International Journal of Stroke . Dec2016, Vol. 11 Issue 9, p1028-1035. 8p. - Publication Year :
- 2016
-
Abstract
- Background: Diffusion-weighted imaging magnetic resonance imaging may detect changes in brain structures remote but connected to stroke consistent with neuropathological descriptions of diaschisis. Early diffusion-weighted imaging demonstrates restriction in corticospinal pathways after arterial ischemic stroke of all ages that correlates with motor outcome. Aim/hypothesis: We hypothesized that cerebral diaschisis is measurable in childhood arterial ischemic stroke and explored associations with outcome. Methods: This sub-study of the validation of the Pediatric NIH Stroke Scale study prospectively enrolled children with acute arterial ischemic stroke and both acute and early follow-up (5-14 days) diffusion-weighted imaging. Inclusion criteria were (1) unilateral middle cerebral artery arterial ischemic stroke, (2) acute and subacute diffusion-weighted imaging (b=1000), and (3) 12 month neurological follow-up (Pediatric Stroke Outcome Measure). A validated method using ImageJ software quantified diffusion-weighted imaging diaschisis in anatomically connected structures. Diaschisis measures were corrected for infarct volume, compared to age, imaging timing, and outcomes (Chi square/Fisher, Mann-Whitney test). Results: Nineteen children (53% male, median 8.1 years) had magnetic resonance imaging at medians of 21 and 168 h post-stroke onset. Diaschisis was common and evolved over time, observed in one (5%) on acute but eight (42%) by follow-up diffusion-weighted imaging. Thalamic and callosal diaschisis were most common (5, 26%). Estimates of perilesional diaschisis varied (54±18% of infarct volume). Children with diaschisis tended to be younger (7.02±5.4 vs. 11.82±4.3 years, p=0.08). Total diaschisis score was associated with poor cognitive outcomes (p=0.03). Corticospinal tract diaschisis was associated with motor outcome (p=0.004). Method reliability was excellent. Conclusions: Diffusion-weighted imaging diaschisis occurs in childhood arterial ischemic stroke. Mistaking diaschisis for new areas of infarction carries important clinical implications. Improved recognition and study are required to establish clinical relevance. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17474930
- Volume :
- 11
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- International Journal of Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 119574127
- Full Text :
- https://doi.org/10.1177/1747493016666089