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Chiroptical Asymmetric Reaction Screening via Multicomponent Self-Assembly.
- Source :
-
Journal of the American Chemical Society . 10/19/2016, Vol. 138 Issue 41, p13517-13520. 4p. - Publication Year :
- 2016
-
Abstract
- Self-assembly of a stereodynamic phosphine ligand, Pd(II), and a chiral amine, amino alcohol, or amino acid generates characteristic UV and CD signals that can be used for quantitative stereochemical analysis of the bound substrate. A robust mix-and-measure chiroptical sensing protocol has been developed and used to determine the absolute configuration, ee, and yield of an amine produced by Ir-catalyzed asymmetric hydrogenation of an iminium salt. The analysis requires only 1 mg of the crude reaction mixture and minimizes cost, labor, time, and waste. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 138
- Issue :
- 41
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 119357005
- Full Text :
- https://doi.org/10.1021/jacs.6b08892