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Evaluation of Lethal Giant Larvae as a Schistosomiasis Vaccine Candidate.
- Source :
-
BioMed Research International . 11/9/2016, Vol. 2016, p1-7. 7p. - Publication Year :
- 2016
-
Abstract
- Schistosomiasis is a neglected tropical disease of humans, and it is considered to be the second most devastating parasitic disease after malaria. Eggs produced by normally developed female worms are important in the transmission of the parasite, and they responsible for the pathogenesis of schistosomiasis. The tumor suppressor gene lethal giant larvae (lgl) has an essential function in establishing apical-basal cell polarity, cell proliferation, differentiation, and tissue organization. In our earlier study, downregulation of the lgl gene induced a significant reduction in the egg hatching rate of Schistosoma japonicum (Sj) eggs. In this study, the Sjlgl gene was used as a vaccine candidate against schistosomiasis, and vaccination achieved and maintained a stable reduction of the egg hatching rate, which is consistent with previous studies, in addition to reducing the worm burden and liver egg burden in some trials. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEIN analysis
*SCHISTOSOMIASIS prevention
*ANIMAL experimentation
*ELECTROPHORESIS
*ENZYME-linked immunosorbent assay
*GENES
*GENETIC techniques
*IMMUNOGLOBULINS
*MICE
*POLYMERASE chain reaction
*PROBABILITY theory
*RESEARCH funding
*T-test (Statistics)
*TREMATODA
*VACCINES
*DRUG development
*DATA analysis software
*DESCRIPTIVE statistics
*ONE-way analysis of variance
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2016
- Database :
- Academic Search Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 119356237
- Full Text :
- https://doi.org/10.1155/2016/4680812