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Serum miR-95-3p is a diagnostic and prognostic marker for osteosarcoma.
- Source :
-
SpringerPlus . 11/10/2016, Vol. 5 Issue 1, p1-6. 6p. - Publication Year :
- 2016
-
Abstract
- It has been demonstrated that microRNAs (miRNAs or miRs) can act as prognostic and diagnostic markers, and potential therapeutic targets. miR-95-3p has been reported to be downregulated in osteosarcoma tissues, but its potential as a serum biomarker has not been assessed in human osteosarcoma. The purpose of the present study was to examine the expression levels of miR-95-3p in serum of patients with osteosarcoma and to investigate the diagnostic and prognostic value of miR-95-3p. The serum levels of miR-95-3p in osteosarcoma patients were detected by a real-time quantitative reverse transcription-polymerase chain reaction assay. Associations between miR-95-3p expression and various clinicopathological characteristics were analyzed using Chi square test. Differences in patient survival were determined using the Kaplan-Meier method and a log-rank test. A Cox proportional hazards regression analysis was used for multivariate analyses of prognostic values. Compared to healthy controls, the expression levels of miR-95-3p in serum of osteosarcoma patients were significantly decreased ( P < 0.0001). Low miR-95-3p expression had significant association with clinical stage ( P < 0.001) and metastasis ( P < 0.001). The Kaplan-Meier curve showed that patients with high miR-95-3p expression survived significantly longer than patients with low miR-95-3p expression ( P = 0.017). Multivariate analysis demonstrated that miR-95-3p expression level ( P = 0.014) was an independent prognostic biomarker for overall survival. Our findings suggested that down-expression of serum miR-95-3p might be associated with poor prognosis of osteosarcoma patients, suggesting that decreased expression of serum miR-95-3p may serve as a valuable diagnostic/prognostic marker for osteosarcoma patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MICRORNA
*OSTEOSARCOMA
*GENE expression
*METASTASIS
*CANCER genetics
Subjects
Details
- Language :
- English
- ISSN :
- 21931801
- Volume :
- 5
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- SpringerPlus
- Publication Type :
- Academic Journal
- Accession number :
- 119355828
- Full Text :
- https://doi.org/10.1186/s40064-016-3640-0