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The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: Modifications at C-12.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Nov2016, Vol. 26 Issue 22, p5492-5496. 5p. - Publication Year :
- 2016
-
Abstract
- A series of 12-oxime and O -oxime ether derivatives of dehydroabietic acid were synthesized and investigated for the antibacterial activity against Staphylococcus aureus Newman strain and five multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108, and NRS-271). The aromatic oximate derivative 11a showed the highest activity with MIC of 0.39–0.78 μg/mL against S. aureus Newman. Of note, compounds 10b , 11 and 14 showed the most potent antibacterial activity against five multidrug-resistant S. aureus with MIC values of 1.25–3.13 μg/mL. These results offered useful information for further strategic optimization in search of the antibacterial candidates against infection of multidrug-resistant Gram-positive bacteria. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 26
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 119159689
- Full Text :
- https://doi.org/10.1016/j.bmcl.2016.10.018