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Cardiovascular magnetic resonance patterns of biopsy proven cardiac involvement in systemic sclerosis.
- Source :
-
Journal of Cardiovascular Magnetic Resonance (BioMed Central) . 10/21/2016, p1-9. 7p. 3 Black and White Photographs, 2 Charts. - Publication Year :
- 2016
-
Abstract
- Background: To determine morphological and functional cardiovascular magnetic resonance (CMR) patterns in histopathologically confirmed myocardial involvement in patients with systemic sclerosis (SSc). Methods: Twenty patients (6 females; mean age 41 ± 11 years) with histopathologically proven cardiac involvement in SSc in the years 2008-2016 were retrospectively evaluated. Morphological, functional and late gadolinium enhancement (LGE) images were acquired in standard angulation sat 1.5T CMR. Pathologies were categorized: 1) Pericardial effusion; 2) pathologic left (LV) or right ventricular (RV) contractility (hypokinesia, dyssynchrony, and diastolic restriction); 3) reduced left (LV-EF) and right ventricular ejection fraction (RV-EF); 4) fibrosis and/or inflammation (positive LGE); 5) RV dilatation. 95 % confidence intervals (CI) were calculated for appearance of pathologic EF and RV dilatation. Results: Seven patients (35 %) had positive CMR findings in three categories, 9 patients (45 %) in four categories and 4 patients (20 %) in five categories. The distribution of pathologic findings was: minimal pericardial effusion in 7 patients (35 %), moderate pericardial effusion >5 mm in nine patients (45 %); abnormal LV or RV contractility in 19 patients (95 %), reduced LV or RV function in 14 patients (70 %; 95 % CI: 51-88 %), pathologic LGE in all patients, RV dilatation in 6 patients (30 %; 95 % CI: 15-54 %). Conclusions: CMR diagnosis of myocardial involvement in SSc requires increased attention to subtle findings. Pathologic findings in at least three of five categories indicate myocardial involvement in SSc. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARDIOMYOPATHIES
*BIOPSY
*CONFIDENCE intervals
*HISTOLOGICAL techniques
*MAGNETIC resonance imaging
*RHEUMATIC heart disease
*SCALE analysis (Psychology)
*STATISTICAL hypothesis testing
*STATISTICS
*SYSTEMIC scleroderma
*T-test (Statistics)
*INTER-observer reliability
*CONTRAST media
*RETROSPECTIVE studies
*BODY surface area
*DATA analysis software
*DESCRIPTIVE statistics
*DISEASE complications
*CARDIOVASCULAR diseases risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 1532429X
- Database :
- Academic Search Index
- Journal :
- Journal of Cardiovascular Magnetic Resonance (BioMed Central)
- Publication Type :
- Academic Journal
- Accession number :
- 119103630
- Full Text :
- https://doi.org/10.1186/s12968-016-0289-3