The synthesis of novel N -heterocyclic α-diphenylphosphinoglycines.

The one-pot reaction ofglyoxylic acid hydrate withdiphenylphosphine and a heretocyclic primary amine in methanol results in formation of first examples of N-hererocyclic α-diphenylphosphinoglycines bearing imidazo[4,5-d]-pyrimidine-6-yl, 4,6-dimethylpyrimidin-2-yl, pyridine-2-yl and pyridine-3-yl substituents. [ABSTRACT FROM PUBLISHER]