抗高血压药与骨质疏松症.

Osteoporosis and hypertension share common risk factors and pathological mechanism，they occur mostly in the elderly． The two diseases may coexist in a single individual． Therefore，at the time of using antihypertensive drugs，the impact of the drugs in bone mineral density and in fragile bone fractures should be considered． Current evidences show that loop-acting diuretics are harmful to bone． In contrast，thiazide diuretics，β-blockers，and renin-angiotensin-aldosterone system agent are beneficial to bone by increasing bone mineral density and strength，and diseasing the prevalence of osteoporosis． However，more laboratory evidence and double-blinded，randomized clinical experiments are needed to support the correlation between osteoporosis and hypertension and the preventive effect of bone loss by antihypertensive drugs． [ABSTRACT FROM AUTHOR]