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THE VALUE OF ELASTIC MODULUS INDEX AS A NOVEL SURROGATE MARKER FOR CARDIOVASCULAR RISK STRATIFICATION BY DIMENSIONAL SPECKLE-TRACKING CAROTID ULTRASONOGRAPHY.
- Source :
-
Journal of Cardiovascular Ultrasound . Sep2016, Vol. 24 Issue 3, p215-222. 8p. - Publication Year :
- 2016
-
Abstract
- BACKGROUND: Carotid intima media thickness (CIMT) and the presence of carotid plaque have been used for risk stratification of cardiovascular disease (CVD). To date, however, the association between multi-directional functional properties of carotid artery and CVD has not been fully elucidated. We sought to explore the multi-directional mechanics of the carotid artery in relation to cardiovascular risk. METHODS: Four hundred one patients who underwent carotid ultrasound were enrolled between January 2010 and April 2013. A high risk of CVD was defined as more than 20% of 10-year risk based on the Framingham risk score. Using a speckle-tracking technique, the longitudinal and radial movements were analyzed in the B-mode images. Peak longitudinal and radial displacements, strain and strain rate were also measured. Beta stiffness and elastic modulus index were calculated from the radial measurements. RESULTS: Of the overall sample, 13% (52) of patients comprised the high-risk group. In multivariate logistic regression, CIMT and elastic modulus index were independently associated with a high-risk of CVD {odds ratio (OR): 1.810 [95% confidence interval (Cl) 1.249-2.622] and OR: 1.767 (95% Cl: 1.177-2.652); p = 0.002, 0.006, respectively}. The combination of CIMT and elastic modulus index correlated with a high-risk of CVD more so than CIMT alone. CONCLUSION: The elastic modulus index of the carotid artery might serve as a novel surrogate marker of high-risk CVD. Measurement of the multi-directional mechanics of the carotid artery using the speckle tracking technique has potential for providing further information over conventional B-mode ultrasound for stratification of CVD risk. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ELASTIC modulus
*CARDIOVASCULAR diseases
*CAROTID artery ultrasonography
Subjects
Details
- Language :
- English
- ISSN :
- 19754612
- Volume :
- 24
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Cardiovascular Ultrasound
- Publication Type :
- Academic Journal
- Accession number :
- 118712506
- Full Text :
- https://doi.org/10.4250/jcu.2016.24.3.215