Back to Search
Start Over
De Novo Asymmetric Synthesis of Phoracantholide J.
- Source :
-
Organic Letters . Oct2016, Vol. 18 Issue 19, p4970-4973. 4p. - Publication Year :
- 2016
-
Abstract
- A de novo asymmetric total synthesis of the macrolide natural product (S)-phoracantholide J has been achieved in 10 steps from the commodity chemicals (1-pentyne, ethyl acrylate, acetaldehyde, and hydrogen). The asymmetry of the route was introduced by a Noyori reduction of a 3-yn-2-one, which makes the route equally amenable to the synthesis of either enantiomer. In addition, this route relies upon an alkyne zipper, a hydroalkynylation, and a macrolactonization to complete the synthesis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 18
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 118665627
- Full Text :
- https://doi.org/10.1021/acs.orglett.6b02432