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Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor.
- Source :
-
Science . 9/30/2016, Vol. 353 Issue 6307, p1553-1556. 4p. 4 Graphs. - Publication Year :
- 2016
-
Abstract
- Animals adapt their growth rate and body size to available nutrients by a general modulation of insulin–insulin-like growth factor signaling. In Drosophila, dietary amino acids promote the release in the hemolymph of brain insulin-like peptides (Dilps), which in turn activate systemic organ growth. Dilp secretion by insulin-producing cells involves a relay through unknown cytokines produced by fat cells. Here, we identify Methuselah (Mth) as a secretin-incretin receptor subfamily member required in the insulin-producing cells for proper nutrient coupling. We further show, using genetic and ex vivo organ culture experiments, that the Mth ligand Stunted (Sun) is a circulating insulinotropic peptide produced by fat cells. Therefore, Sun and Mth define a new cross-organ circuitry that modulates physiological insulin levels in response to nutrients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DROSOPHILA
*INSULIN
*LIGANDS (Biochemistry)
*ADIPOSE tissues
*AMINO acids
*HEMOLYMPH
Subjects
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 353
- Issue :
- 6307
- Database :
- Academic Search Index
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- 118517843
- Full Text :
- https://doi.org/10.1126/science.aaf8430