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Coronary heart disease mortality, plasma homocysteine, and B-vitamins: a prospective study
- Source :
-
Atherosclerosis (00219150) . Feb2003, Vol. 166 Issue 2, p369. 9p. - Publication Year :
- 2003
-
Abstract
- The results of prospective studies on the relations between the plasma concentration of total homocysteine (tHcy) and B-vitamins, on the one hand, and coronary heart disease (CHD) mortality, on the other hand, are inconclusive and scarce considering the relation with B-vitamins. We prospectively determined these relations in a case-cohort study. The full-cohort existed in ∼36,000 Dutch adults aged 20–59 years at baseline. The statistical analyses were done with a random sample from the cohort (n=630) complemented with all subjects who died of CHD (n=102) during a mean follow-up of 10.3 years. All subjects reported the absence of cardiovascular diseases (CVDs) at baseline. The plasma concentrations of tHcy, folate, PLP, and vitamin B12 were determined in samples obtained at baseline. Men with a tHcy concentration in the highest tertile (T3) compared with men in the lowest tertile (T1) had a relative risk (RR) of 1.14 for CHD (95% confidence interval (CI): 0.50, 2.61) after adjusting for age, study center, hypertension, HDL and total cholesterol, smoking, and creatinine. For women, this RR was 2.04 (95% CI: 0.48, 8.62). For each 5 μmol/l increase in tHcy, the RR of CHD was 1.03 (95% CI: 0.83–1.29) for men and women combined. In women only, high folate levels were associated with a statistically significant protection of fatal CHD (T3 versus T1; RR: 0.22, 95% CI: 0.06, 0.87). Plasma PLP (B6) and vitamin B12 concentrations were not associated with CHD risk. We conclude that elevated tHcy concentrations do not seem to be a risk factor for CHD mortality in these relatively young healthy Dutch subjects free of baseline CVD. Higher folate concentrations may be protective of CHD, but this needs confirmation. [Copyright &y& Elsevier]
- Subjects :
- *BLOOD plasma
*CORONARY disease
*MORTALITY
*VITAMINS
Subjects
Details
- Language :
- English
- ISSN :
- 00219150
- Volume :
- 166
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Atherosclerosis (00219150)
- Publication Type :
- Academic Journal
- Accession number :
- 11850438
- Full Text :
- https://doi.org/10.1016/S0021-9150(02)00373-8