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Cisplatin-crosslinked glutathione-sensitive micelles loaded with doxorubicin for combination and targeted therapy of tumors.

Authors :
Zhang, Xueqiong
Li, Lianghong
Li, Chunfu
Zheng, Hua
Song, Haoyuan
Xiong, Fuliang
Qiu, Tong
Yang, Jin
Source :
Carbohydrate Polymers. Jan2017, Vol. 155, p407-415. 9p.
Publication Year :
2017

Abstract

The delivery of combination chemotherapy by nanoscale platforms has been demonstrated to enhance cancer treatment in the clinic. Cisplatin (CDDP)-crosslinked, glutathione-sensitive, tumor-targeting micelles based on carboxymethyl chitosan were designed for synergistic cisplatin-doxorubicin (DOX) combination chemotherapy. In our study, DOX was conjugated to carboxymethyl chitosan through a disulfide bond, which was structurally characterized by 1 H NMR. The micelles formed by self-assembly were spherical, with the mean diameter of 274 nm. The in vitro release studies revealed that the micelles were highly glutathione-sensitive. Cytotoxicity analysis demonstrated that the cisplatin-crosslinked micelles loaded with DOX exhibited enhanced therapeutic efficacy compared with the DOX-loaded nanoparticles, free DOX, and free CDDP. Cellular uptake and intracellular release revealed that the cisplatin-crosslinked micelles loaded with DOX could efficiently deliver and release DOX into the cancer cells. These results clearly indicate that tumor-targeting and glutathione-sensitive micelles provide means for combination drug delivery in cancer treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01448617
Volume :
155
Database :
Academic Search Index
Journal :
Carbohydrate Polymers
Publication Type :
Academic Journal
Accession number :
118498564
Full Text :
https://doi.org/10.1016/j.carbpol.2016.08.072