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Synthetic studies on enfumafungin: stereoselective synthesis of the CD ring segment.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Oct2016, Vol. 57 Issue 43, p4838-4841. 4p. - Publication Year :
- 2016
-
Abstract
- The stereoselective synthesis of the right-hand segment of enfumafungin, a potent antifungal agent isolated from a Hormonema sp., was achieved. The contiguous two quaternary carbon atoms at the angular positions of the trans -fused CD ring system was constructed through the stereoselective reduction of 4-cyano-3,4-dimethyl-2-cyclohexen-1-one and the Johnson–Claisen rearrangement. After elongation of the side chains, the D ring was formed via a stereoselective intramolecular conjugate addition reaction which was originally developed by our laboratory. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 57
- Issue :
- 43
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 118467264
- Full Text :
- https://doi.org/10.1016/j.tetlet.2016.09.057