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Prolactin response to nemonapride, a new antipsychotic drug, in schizophrenic patients.
- Source :
-
Human Psychopharmacology: Clinical & Experimental . Nov/Dec97, Vol. 12 Issue 6, p591-594. 4p. 1 Chart, 1 Graph. - Publication Year :
- 1997
-
Abstract
- The prolactin response to nemonapride, a new antipsychotic drug, was studied in 27 schizophrenic inpatients (12 males, 15 females). The daily dose of nemonapride was 18 mg/day, and the duration of treatment was 3 weeks. Plasma prolactin concentrations were measured by enzyme immunoassay. Nemonapride treatment significantly (p <0·01) increased prolactin concentrations at each week in both genders. The Δprolactin (the mean concentration during 3 weeks minus the pretreatment concentration) was significantly (p <0·01) greater in females (mean± SD, 81·6±57·8 ng/ml) than males (34·9±19·8 ng/ml). The present study thus shows that nemonapride treatment markedly increases prolactin concentrations in schizophrenic patients, with greater responses in females than males, suggesting a strong D2 receptor blockade property of the drug. © 1997 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08856222
- Volume :
- 12
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Human Psychopharmacology: Clinical & Experimental
- Publication Type :
- Academic Journal
- Accession number :
- 11822031
- Full Text :
- https://doi.org/10.1002/(SICI)1099-1077(199711/12)12:6<591::AID-HUP926>3.0.CO;2-U