HELICOBACTER PYLORI: FATOR ASSOCIADO AO CÂNCER DE PULMÃO EM FUMANTES.

BACKGROUND: lung cancer is the most common malignant tumors, and in Brazil the type of cancer that did more victims, and in 90 % of cases are associated with the consumption of tobacco products. However, in approximately 80 % of smokers never develop. Different types of microorganisms have been associated with oncogenes processes for more than a century. To the group of bacteria, Helicobacter pylori was first recognized that causes gastric cancer may be related to lung cancer by these develop from them endoderm cells that form the lining of the gastrointestinal tract. OBJECTIVE: contribute to the possible correlation to a factor beyond the known potential of lung cancer. METHODOLOGY: A survey in HRJF patients, the year 2010-2013 with lung cancer diagnosis. We have found 31 patients of which 13 were selected patients. From each of the 13 pieces were collected fragments of their tumor and non-tumor part, resulting in 26 new pieces; them to look for the presence of H. pylori by immunohistochemistry. RESULTS: of the 26 pathological parts for H. pylori, 22 were positive and 4 negative. Parts of the positive patients, 11 were tumor and 11 non-tumor, which corresponded to 11 patients, with the result that each patient was positive for its two samples. Being OR = 1, means that the chances of a patient has H. pylori is equal in tumor tissue and non-tumor. DISCUSSION: Given the results of previously published studios that support a positive association and other zero for the hypothesis of an association between H. pylori and lung cancer, in our cross-sectional study avoiding confounding factors were not found no evidence of an association between H. pylori and lung cancer. The results were also null for the histological type, and the analysis of gender and no significant mortality. CONCLUSION: Although it has observed the presence of H. pylori in the lung tissue of smokers with lung cancer, It can not say based on our results that H. pylori is associated with lung carcinogenesis. [ABSTRACT FROM AUTHOR]