内质网应激分子 GRP78 对非小细胞肺癌的诊断价值研究.

Objective: To explore the diagnostic value of glucose regulated protein 78 (GRP78) of endoplasmic reticulum stress molecules for non small cell lung cancer (NSCLC). Method: A total of postoperative carcinoma tissue specimens of 45 patients with NSCLC were selected, from which 18 cases of adjacent to carcinoma tissues were selected at the same time. The expressions was used to of GRP78 of all the selected tissues were detected by Real-time PCR and analyzed the correlation of the expression of GRP78 in NSCLC tissues with clinical characteristics and the survival periods of the patients. Results: The expression levels of GRP78 in NSCLC tissues were much higher than those in para-cancerous tissues, the differences were statistically significant (p<0.05). The expression levels of GRP78 in the cancer tissues of patients with NSCLC at stage Ⅲ a were much higher than those at stage Ⅰ-Ⅱ, the differences were statistically significant (P<0.05). Kaplan-Meier analysis showed that the survival periods of patients with high expression level of GRP78 were shorter than low expression level of GRP78 (P<0.05). Conclusion: The expression of GRP78 May be related to the occurrence and development of tumor cells and the survival periods of patients, which can be used as an important biomarker of forecasting diagnosis and treatment of NSCLC patients. [ABSTRACT FROM AUTHOR]