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Upregulation of Nrf2–p300 mediates anti-inflammatory effects of curcumin in microglia by downregulating p65–p300.
- Source :
-
Animal Cells & Systems . Oct2016, Vol. 20 Issue 5, p246-252. 7p. - Publication Year :
- 2016
-
Abstract
- Curcumin (CUR) is a hydrophobic polyphenol derived from the rhizome ofCurcuma longa. CUR confers protection in various pathological conditions, including many brain-related diseases, such as cerebral ischemia, intracerebral hemorrhage, or Alzheimer’s disease, and these effects have been attributed to its anti-inflammatory and anti-oxidative properties. In the present study, we found CUR induced the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in microglia, brain macrophage, and thus upregulated genes downstream of antioxidant response element, such as heme oxygenase 1, NAD(P)H:quinone oxidoreductase 1, glutamate-cysteine ligase modifier subunit, and ferritin light chain, and simultaneously downregulated lipopolysaccharide-induced inducible nitric oxide synthase expression. We showed that the anti-inflammatory effect of CUR in microglia is connected with its anti-oxidative effect in that CUR promotes Nrf2–p300 binding at the expense of p65–p300 binding. Since CUR is a dietary spice that is eaten on a daily basis, it appears that CUR could be used therapeutically to induce anti-oxidative effect and simultaneously ameliorate inflammatory conditions via up–downregulation of related genes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19768354
- Volume :
- 20
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Animal Cells & Systems
- Publication Type :
- Academic Journal
- Accession number :
- 118114698
- Full Text :
- https://doi.org/10.1080/19768354.2016.1223169